ACT! AP is currently being represented by 30 individual and organisational members in 15 countries across Asia and the Pacific. Under the leadership of its new Steering Committee for 2024-2026, ACT! AP has adopted a new set of Commitments to Action that will guide its regional priorities and advocacy for the next two years. These new Commitments to Action represent ACT! AP’s response to complement the commitments and address the regional gaps around the 2023 UN Political Declaration on TB. This brief provides contextual understanding and regional priorities of ACT! AP under each Commitment to Action, with a purpose of guiding and supporting ACT! AP members and broader civil society and communities in the region as we jointly advocate towards TB-free Asia-Pacific by 2035.