PEPFAR’s Key Population Investment Fund (KPIF) is a $100 million new funding stream made available for five-years by the US State Department through the Office of the Global AIDS Coordinator and Health Diplomacy (S/GAC) to support the scale up of key population-led approaches to improve and enhance HIV prevention, treatment, care and support services for key populations. Here are some points to consider if you are considering to apply:

  • The KPIF ultimately aims to improve quality service delivery for key populations, resulting in increased HIV testing coverage for key populations, improved linkage to HIV prevention and HIV treatment services, and viral load suppression. It is designed to support both “proven and innovative” community-led interventions around critical enablers, including provision of direct services that fit into programme objectives, that overcome barriers to improve accessibility, acceptability, uptake, coverage, effectiveness and efficiency of HIV services for key populations.
  • This funding stream has five focus areas:
  1. Scaling up demand and access to quality and effective HIV services for key populations;
  2. Structural barriers that inhibit access to quality and effective HIV services for key populations, or undermine their effectiveness. These include barriers in laws and policies or their enforcement, education, or economic barriers;
  3. Addressing and monitoring stigma and discrimination at individual, community, and national levels;
  4. Promoting human rights and justice for all; and
  5. Collecting and analyzing data for key populations and sub-populations.
  • KPIF aims to support groups as Prime Recipients for grant requests for $500,000 to $10,000,000 for up to four years. Prime Recipients may sub-award grants to other groups for up to $150,000 every year for up to three years. Submitting applications as consortium of organisations is highly encouraged, although only one group will be awarded as Prime Recipient. Prime Recipients are expected to engage sub-awardees, especially to KP-led community groups that do not meet the criteria to be Prime Recipients.
  • A funding application may cover one or more of these key populations: gay men and other men who have sex with men (MSM); sex workers (SW); people who inject drugs (PWID); and people in prison and other closed settings.
  • Technical assistance and capacity-building may be supported by the KPIF, and Prime Recipients are expected to work with sub-awardees to identify capacity gaps for programme impact and post-grant sustainability to ensure that capacity needs are provided for in the grant programme.
  • KPIF is designed to avoid duplication, and therefore Prime Recipients must be knowledgeable of KP programs being supported in target countries by PEPFAR, Global Fund, UN agencies, bilateral donors, and other funding organisations.
  • KPIF covers the following regions: West and Central Adrica, Eastern Europe/Central Asia, East and Southern Africa (Sub-Saharan Africa), Latin America, Carribean, and Asia and the Pacific. In Asia-Pacific region, the eligible countries are the following: Burma, Cambodia, China, india, indonesia, Laos, Nepal, Papua New Guinea, Thailand, and Vietnam.
  • These US-based or foreign-based entities are eligible to apply: non-profit organisations; non-government organisations; faith-based organizations; community-based organizations; private, public or state institutions of higher education; and for-profit organizations or businesses. Applications from individuals, foreign governments or affiliated groups will not be accepted.
  • Application format, including narrative sections and budget, and other grant eligibility requirements, are available in the Notice of Funding Opportunity.

Application deadline: by 11:59pm EDT 21 October 2016. For inquiries about the KPIF, please email [email protected].

Get a copy of the executive summary of the NOFO, FAQs on the KPIF, and PEPFAR’s Key Populations Factsheet here.

Technical preparations

For KP networks and community groups, applying for big grants can be a daunting and challenging experience. For this funding stream, due diligence is required from the applicants. Please note of these technical requirements if you are considering applying:

  • All applications are to be submitted online, via or All information on KPIF are available on both sites.
  • Applications from organisations with no previous or existing grants managed by the Office of Grants Management will have to go through Download the Application Package for Funding Opportunity No. SBUR-SOGAC-17-001, complete the package, and submit it via the website. You need an active username and password, an active SAM (or System Award Management) registration number, and the completed package.
  • Applications from existing or previous grants and are applying as part of an ongoing grantee activity can apply via using their existing username and password and their SAM number.
  • A SAM registration is required to be eligible of financial assistance from the US government. It consolidates other registration and certification requirements for awardees, vendors, or contractors. The SAM registration process may take three days to two weeks for new applicants, and it requires a DUNS number and your Tax Identification Number, among others. Go to to register.
  • DUNS, or Dun & Bradstreets (D&B) ‘Data Universal Numbering System’, refers to a copyrighted means to identify business entities. Getting the nine-character DUNS number is free of charge. To register, the following information is required: legal name of the organisation, address, phone number, name of CEO or owner, type of business (corporation, non-profit, etc), year of establishment, primary line of business, number of employees. Application may done via a toll-free number (1-866-7055711) or online (